As we age, neurons build up damage to DNA, and repairing that DNA could no doubt reverse cognitive impairment with age. This is the bet of this team from the Massachusetts Institute of Technology (MIT) which demonstrates here, in animals…
ELISA PROTOCOL
An ELISA, or Enzyme-linked immunosorbent assay, is a straightforward and efficient assay used within the quantitative measurement of each secreted and intracellular protein targets in organic samples resembling cell lysates or serum. ELISA assays are strong, delicate and particular. Due to…
Western Blot Tips and Tricks
What is Western Blot? If it is advisable establish particular amino-acid sequences from a pattern, Western Blotting is the approach it is best to select. Target proteins are marked utilizing fastidiously chosen major and secondary antibodies that allow you to…
Near-optimal experimental design for model selection in systems biology.
BACKGROUNDBiological systems are understood by means of iterations of modeling and experimentation. Not all experiments, nevertheless, are equally worthwhile for predictive modeling. This examine introduces an environment friendly methodology for experimental design geared toward deciding on dynamical fashions from information.…
White spotting variant mouse as an experimental model for ovarian aging and menopausal biology.
OBJECTIVEMenopause is a singular phenomenon in trendy girls, as most mammalian species possess a reproductive interval comparable with their life span. Menopause is brought on by the depletion of germ cell-containing ovarian follicles and in laboratory research is normally modeled…
Synthesis of Experimental Molecular Biology and Evolutionary Biology: An Example from the World of Vision.
Natural choice has performed an essential position in establishing varied phenotypes, however the molecular mechanisms of phenotypic adaptation should not properly understood. The gradual progress is a consequence of mutagenesis experiments through which present-day molecules had been used and of…
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